... 7000 of an estimated 80 000 human genes have already been mapped to particular chromosomes. The goal of physical mapping is to produce a genome map consisting of approximately 30 000 markers separated by about 100 kilobases. Each marker will be a sequence-tagged site, a stretch of DNA with a unique and well-defined sequence. Sequencing, that is, the listing of the order of the approximately three billion base pairs that make up the human genome, is the final planned step of the project. Also key is the pursuit of advances in technology, including robotics, automation, and new methods of identifying and mapping genes, to allow large-scale sequencing. The storing and analysing of the vast amounts of data generated by the project are also a consideration, and requires the development of new database tools and software. The benefits of sequencing the human genome are expected to be enormous. We will have information ...

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