... that it persists over time, as well as the fact that can be rapidly induced, is associative and depends on correlated presynaptic and postsynaptic activity. This account will review the neurobiological evidence for LTP as a mechanism, then go on to outline some of the evidence that it in fact is the neurobiological basis of learning and memory. The neurological basis of Long Term Potentiation The phenomenon of Long Term Potentiation (LTP) was originally chronicled by Bliss and Lomo in 1973; when they reported that stimulation of the perforant path leading to the dentate gyrus in the hippocampus of a rabbit caused a potentiation of the response in these cells. LTP can be generated by activating the afferent pathway such that a stable excitatory postsynaptic potential (EPSP) can be measured in the postsynaptic cell. If a conditioning tetanus (or conditioning train as Bliss and Lomo called it) is then applied, in the ...

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