... other people is duly acknowledge in references, and/or footnotes. I also understand that plagiarism and collusion are serious offences and that if I am guilty of either my work may be disqualified and I may face other disciplinary action. Signed: ........ Date: 24/03/03..................... The Role of Wnt Signalling in Neural Crest Development Noel Slattery w0036323 The neural crest is a transient structure that extends along the rostro-caudal axis of developing vertebrate embryos. It comes into existence during the final stages of neurulation. The primary embryonic induction initiates and controls neurulation. The notochord and adjacent mesoderm interact with the overlying dorsal ectoderm. This interaction induces the ectoderm to thicken, flatten and rise above the surrounding ectoderm, forming the neural plate. This thickening is caused by cell shape changes. The edges of the plate are drawn up by further cell shape changes into neural folds. The embryo becomes separated into two halves by the appearance of the neural groove ...

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